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In the years following Dr. Pistor's discovery, Mesotherapy was used to treat medical conditions such as osteoarthritis, fibromyalgia, chronic pain, depression and anxiety. However, French practitioners soon discovered that the technique could be used to treat skin conditions such as cellulite, stretch marks, wrinkles, hair loss and acne. In addition, Mesotherapy can promote weight loss, and is used in body sculpting and firming of the skin.

Orally administered medications suffer from a disadvantage: they must first pass through the gastrointestinal tract and liver before they are released into the bloodstream. This significantly reduces the amount of medication that actually reaches the afflicted area. Only a small portion of medicine designed to treat a knee inflammation, for example, actually arrives at the knee. Most of the medication is distributed throughout the body in diluted form. By contrast, Mesotherapy uses a much smaller dose of the same medicine, which is injected near the knee. Because the skin acts as an efficient time-release delivery system, the remedy is faster and longer lasting.

Mesotherapy is practiced in countries around the world, including the U.K., France, Switzerland, Belgium, the United States and several South American nations.

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